Comparative study of importance of different macromolecules (Polymers) on the development of novel dosage form

The purpose of the current research is to reduce dosing frequency and improve patient compliance by designing and systematically evaluating sustained release microbeads of Tacrolimus. The present research high-lights the formulation and evaluation of Tacrolimus loaded microbeads prepared by ionotropic gelation and crosslinking technique by using polymers such as chitosan and xanthan gum while sodium alginate being the common polymer with a cross linking agent being calcium chloride. Formulated microbeads were evaluated for particle size, percent yield, drug entrapment efficacy, invitro release, release kinetic and stability study.  http://solidstatetechnology.us/index.php/JSST/article/view/8740