Evaluation of Anti-Inflammatory and Anti-Microbial Activities of Omani Pomegranate Peel Extract Using LPS-Stimulated Human Macrophages

Pomegranate (Punica granatum L.) is rich in Phenolic acids and flavonoids components which are known for their pharmacological and therapeutic activities. These activities depended on the concentration of these bioactive compounds in the plant extract. Hence, the present study aims to optimize the extraction of polyphenols and flavonoids from the peel of one of the Omani pomegranate variety using two different drying methods and different solvents and studying their antimicrobial effect. The peels were dried using air and oven drying methods and were further analyzed to identify and quantify the bioactive compounds and compare the effect of drying methods and the type of solvents on the concentrations of the bioactive compounds using HPLC and GC/MS. The aim of the study is to identify and quantify the bioactive compounds from Omani pomegranate peel using two different drying methods and solvents and  studying the antimicrobial effect.

Major Objectives: (i) Evaluate the effects of drying methods on the bioactive compounds of Omani pomegranate peel. (ii) Characterize the chemical profile of peel extracts collected using different extraction solvents. (iii) Evaluated the potential antibacterial effects of Omani pomegranate peel extract

Research Team:

(i) Miss. Moza Alrisi (PI) (ii)Dr Souad Al-Okla (Supervisor) (iii) Dr Nasser Al Nazwani (Co-PI) (iv) Dr Nida Al wadi (Co-Inv.) (v) Dr Jamal Al-Sabahi (Co-Inv.) (vi)  Dr Ciraj Mohammed (Co-Inv.) (vii) Mariya Alhilali (viii)Aisha Al Battashy (ix) Sidrah Khan (x) Arwa Al Mujaini