Objectives: Irritable bowel syndrome (IBS) is a globally common functional gastrointestinal disorder which mainly affects people with high levels of stress. Given that medical students are presumably exposed to higher levels of stress in comparison to others, this study aims to assess the prevalence of IBS in Medical students as well as possible associated risk factors. Method: A cross-sectional study was carried out at the National University of Technology and Health Sciences, College of Medicine, Oman during the period between 1 June and 2 July 2017. A comprehensive self-administered questionnaire was used to cover the following aspects : Age and gender, grade, possible triggers or risk factors, Rome IV Criteria, generalised anxiety score and family history of IBS. Results: A total of 464 students participated in the study, from which 38.9% (n=179) were detected to have IBS. The identified types of IBS include diarrhea (38.5%), mixed diarrhea and constipation (36.3%) and constipation (25.1%). The prevalence of IBS was higher amongst female students (41.3%). Year 2 students showed the highest prevalence (Students with positive family history of IBS showed higher IBS prevalence rate. The prevalence rate of IBS increased with increased anxiety levels and the difference was almost significant. Conclusion: More than a third of medical students included in our study, have shown symptoms consistent with undiagnosed IBS. It seems that high level of stress (represented by subjective anxiety) might play an important role in such high prevalence. Implementing effective measures to decrease stress levels may be beneficial in dealing with this problem which subsequently reflects positively on students’ quality of life and academic performance. Pages 33 to 44