{"id":7523,"date":"2022-02-17T11:20:21","date_gmt":"2022-02-17T07:20:21","guid":{"rendered":"https:\/\/nu.edu.om\/?p=7523"},"modified":"2022-02-17T07:20:34","modified_gmt":"2022-02-17T07:20:34","slug":"altwlyf-alsmyh-fy-anabyb-almkhtbr-adme-wdrasat-alaltham-aljzyey-lmshtqat-alfwranwn-alhamlh-llbnzymydazwl","status":"publish","type":"post","link":"https:\/\/nu.edu.om\/pharmacy\/altwlyf-alsmyh-fy-anabyb-almkhtbr-adme-wdrasat-alaltham-aljzyey-lmshtqat-alfwranwn-alhamlh-llbnzymydazwl\/","title":{"rendered":"\u0627\u0644\u062a\u0648\u0644\u064a\u0641\u060c \u0627\u0644\u0633\u0645\u064a\u0629 \u0641\u064a \u0627\u0646\u0627\u0628\u064a\u0628 \u0627\u0644\u0645\u062e\u062a\u0628\u0631\u060c ADME\u060c \u0648\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0627\u0644\u062a\u062d\u0627\u0645 \u0627\u0644\u062c\u0632\u064a\u0626\u064a \u0644\u0645\u0634\u062a\u0642\u0627\u062a \u0627\u0644\u0641\u0648\u0631\u0627\u0646\u0648\u0646 \u0627\u0644\u062d\u0627\u0645\u0644\u0629 \u0644\u0644\u0628\u0646\u0632\u064a\u0645\u064a\u062f\u0627\u0632\u0648\u0644"},"content":{"rendered":"\r\n

\u062a\u0645 \u062a\u0635\u0646\u064a\u0639 \u0633\u0644\u0633\u0644\u0629 \u0645\u0646 \u0645\u0634\u062a\u0642\u0627\u062a benzimidazole-furanones (4a-l) \u0648\u062a\u0645\u064a\u064a\u0632\u0647\u0627 \u0648\u0627\u0633\u062a\u0643\u0634\u0627\u0641\u0647\u0627 \u0644\u0623\u0646\u0634\u0637\u062a\u0647\u0627 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0633\u0631\u0637\u0627\u0646 \u0641\u064a \u0627\u0644\u0645\u062e\u062a\u0628\u0631. \u0643\u0634\u0641\u062a \u0627\u0644\u0645\u0639\u0644\u0645\u0627\u062a \u0627\u0644\u062d\u0631\u0643\u064a\u0629 \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0645 \u062a\u0642\u064a\u064a\u0645\u0647\u0627 \u0623\u0646 \u062c\u0645\u064a\u0639 \u0627\u0644\u0645\u0631\u0643\u0628\u0627\u062a \u0627\u062a\u0628\u0639\u062a \u0642\u0627\u0639\u062f\u0629 \u0644\u064a\u0628\u064a\u0646\u0633\u0643\u064a \u0627\u0644\u0645\u0643\u0648\u0646\u0629 \u0645\u0646 \u062e\u0645\u0633\u0629\u060c \u0645\u0645\u0627 \u064a\u062c\u0639\u0644\u0647\u0627 \u0645\u0631\u0634\u062d\u0629 \u0645\u062d\u062a\u0645\u0644\u0629 \u0644\u0644\u0639\u0642\u0627\u0642\u064a\u0631. \u0639\u0644\u0627\u0648\u0629\u064b \u0639\u0644\u0649 \u0630\u0644\u0643\u060c \u0643\u0634\u0641\u062a \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0646\u0634\u0627\u0637 \u0627\u0644\u0645\u0636\u0627\u062f \u0644\u0644\u0633\u0631\u0637\u0627\u0646 \u0623\u0646 (E) \u20105\u2010 (1H \u2010 benzo [d] imidazol \u2010 2 \u2010 yl) \u20103\u2010 (3\u060c4\u060c5 \u2010 \u062a\u0631\u064a\u0645\u064a\u062b\u0648\u0643\u0633\u064a \u0628\u0646\u0632\u064a\u0644\u064a\u062f\u064a\u0646) \u0641\u0648\u0631\u0627\u0646 \u2010 2 (3H) one (4a )\u060c \u0643\u0627\u0646 \u0646\u0634\u0637\u0627\u064b \u0636\u062f A549 \u0648 MCF7 \u0648 DU145 \u0628\u0642\u064a\u0645 IC50 \u062a\u0628\u0644\u063a 10.4 \u00b1 0.39 \u0648 11.1 \u00b1 0.43 \u0648 10.7 \u00b1 0.19 \u0645\u064a\u0643\u0631\u0648\u0645\u062a\u0631 \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a. \u0628\u064a\u0646\u0645\u0627 \u0645\u0631\u0643\u0628 \u0622\u062e\u0631 (E) \u20105\u2010 (1H \u2010 benzo [d] imidazol \u2010 2 \u2010 yl) \u20103 – ([5 \u2010 phenyl] furan \u2010 2 \u2010 yl) furan \u2010 2 (3H) one (4k) \u0645\u0639\u0631\u0648\u0636 \u0623\u064a\u0636\u0627\u064b \u0646\u0634\u0627\u0637 \u062c\u064a\u062f \u0636\u062f A549 \u0648 MCF7 \u0648 DU145 \u0628\u0642\u064a\u0645 IC50 \u062a\u0628\u0644\u063a 11.4 \u00b1 0.39 \u0648 9.1 \u00b1 0.43 \u0648 12.7 \u00b1 0.19 \u0645\u064a\u0643\u0631\u0648\u0645\u062a\u0631 \u0639\u0644\u0649 \u0627\u0644\u062a\u0648\u0627\u0644\u064a. \u0648\u0642\u062f \u062a\u0645 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062f\u0648\u0643\u0633\u0648\u0631\u0648\u0628\u064a\u0633\u064a\u0646 \u0643\u062f\u0648\u0627\u0621 \u0642\u064a\u0627\u0633\u064a. \u0639\u0644\u0627\u0648\u0629\u064b \u0639\u0644\u0649 \u0630\u0644\u0643\u060c \u062a\u0645 \u0625\u062c\u0631\u0627\u0621 \u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0627\u0644\u062a\u062d\u0627\u0645 \u0627\u0644\u062c\u0632\u064a\u0626\u064a \u0644\u062a\u0648\u0641\u064a\u0631 \u0648\u0636\u0639 \u0627\u0644\u0631\u0628\u0637 \u0641\u064a \u0645\u0648\u0627\u0642\u0639 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637 \u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0639\u0627\u0645\u0644 \u0627\u0644\u0646\u0645\u0648 \u0627\u0644\u0628\u0637\u0627\u0646\u064a \u0627\u0644\u0648\u0639\u0627\u0626\u064a (VEGFR). \u0623\u062b\u0628\u062a\u062a \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0627\u0644\u062a\u062d\u0627\u0645 \u0648\u0637\u0627\u0642\u0627\u062a \u0627\u0644\u0631\u0628\u0637 \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0646\u0634\u0627\u0637 \u0627\u0644\u062a\u062c\u0631\u064a\u0628\u064a \u0627\u0644\u0645\u0636\u0627\u062f \u0644\u0644\u0633\u0631\u0637\u0627\u0646 \u0628\u0634\u0643\u0644 \u062c\u064a\u062f. \u0643\u0645\u0627 \u062a\u0645 \u0627\u0644\u0639\u062b\u0648\u0631 \u0639\u0644\u0649 \u0645\u0639\u0644\u0645\u0627\u062a \u062d\u0631\u0643\u064a\u0629 \u0627\u0644\u062f\u0648\u0627\u0621 (ADME) \u0644\u0644\u0645\u0634\u062a\u0642\u0627\u062a \u0627\u0644\u0642\u0648\u064a\u0629 \u0641\u064a \u0646\u0637\u0627\u0642 \u0645\u0642\u0628\u0648\u0644. \u064a\u0628\u062f\u0648 \u0623\u0646 \u0627\u062a\u062d\u0627\u062f\u0627\u062a benzimidazole \u2010 furanonone \u0645\u0635\u062f\u0631 \u0645\u062d\u062a\u0645\u0644 \u0644\u0645\u0632\u064a\u062f \u0645\u0646 \u062a\u0637\u0648\u064a\u0631 \u0627\u0644\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u0642\u0648\u064a\u0629 \u0627\u0644\u0633\u0627\u0645\u0629 \u0644\u0644\u062e\u0644\u0627\u064a\u0627.<\/p>\r\n\r\n\r\n\r\n

\u062d\u0633\u064a\u0646 \u0623\u060c \u0628\u0648\u062a\u0627\u0646\u064a \u0627\u0645\u060c \u0628\u0627\u0631\u0641\u064a\u0646 \u0625\u0633\u060c \u062e\u0627\u0646 \u0627\u0633 \u0623\u060c \u0623\u062d\u0645\u062f \u0623\u060c \u0625\u0642\u0628\u0627\u0644 \u0627\u0645. \u0623.<\/p>\r\n\r\n\r\n\r\n

https:\/\/www.ingentaconnect.com\/content\/bpl\/jccs\/2021\/00000068\/00000002\/art00019<\/a><\/p>\r\n","protected":false},"excerpt":{"rendered":"

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