Cold atmospheric plasma (CAP), a room temperate ionised gas, known as the fourth state of matter isan ionised gas and can be produced from argon, helium, nitrogen, oxygen or air at atmospheric pressureand low temperatures. CAP has become a new promising way for many biomedical applications, such asdisinfection, cancer treatment, root canal treatment, wound healing, and other medical applications. Amongthese applications, investigations of plasma for skin wound healing have gained huge success both in vitro
and in vivo experiments without any known signi\ue000cant negative effects on healthy tissues. The development of
CAP devices has led to novel therapeutic strategies in wound healing, tissue regeneration and skin infectionmanagement. CAP consists of a mixture of multitude of active components such as charged particles, electric
\ue000eld, UV radiation, and reactive gas species which can act synergistically. CAP has lately been recognizedas an alternative approach in medicine for sterilization of wounds by its antiseptic effects and promotion of
wound healing by stimulation of cell proliferation and migration of wound related skin cells. With respectto CAP applications in medicine, this review focuses particularly on the potential of CAP and the known
molecular basis for this action. We summarize the available literature on the plasma devices developed
for wound healing, the current in vivo and in vitro use of CAP, and the mechanism behind it as well as the biosafety issues<\/p>\r\n\r\n\r\n\r\n
Souad Al-Okla, Asoct. Prof. Molecular Biology, Dr. Nasser Al-Nazwani, Assoct prof. Biochemistry, fatin AL-Mudarris, Asst. Prof. Physics<\/p>\r\n\r\n\r\n\r\n