BACKGROUND: Critically ill patients on mechanical\u2011ventilation are always at a higher risk of acquiring ventilator\u2011associated respiratory infections. The current study was intended to determine the antibiotic\u2011resistance pattern of bacteria recovered from the endotracheal (ET) specimens of ventilated patients. MATERIALS AND METHODS: This was a single\u2011centered, retrospective study carried out in a 400\u2011bed tertiary care hospital in Oman. The data of profile and antibiotic resistance pattern of bacterial isolates recovered from ET aspirates of ventilated patients during the period from January 2017 to August 2019 were retrieved from hospital database. The data were analyzed using the Statistical Package for the Social Sciences (SPSS) software version 22 (IBM, Armonk, New York, USA). Descriptive statistics were applied to find the frequencies and percentages. Charts and tables were constructed. RESULTS: In total, 201 bacterial isolates recovered from ET secretions of 154 ventilated patients were studied. The rate of isolation was predominant among males (65.6%) and in elderly people (50%). Gram\u2011negative bacilli (GNB) were predominantly (88.6%) isolated. Acinetobacter baumannii (31.3%) was the most common isolate and 86% of them were multidrug\u2011resistant strains. Klebsiella pneumoniae (23.9%) and Pseudomonas aeruginosa (22.9%) were the other common GNB, whereas Staphylococcus aureus was the most frequently isolated Gram\u2011positive bacteria. Gentamicin showed good in vitro activity against S. aureus and all the GNB except A. baumannii reflecting good choice for empirical therapy. CONCLUSION: Gram\u2011negative bacteria were the predominant isolates in ET secretions of ventilated patients. There was an alarmingly high rate of antimicrobial resistance among GNB. A rational use of antibiotics, regular monitoring of antibiotic resistance and use of right combination of drugs, in addition to refining of existing infection control practices are critical to control the emergence of drug\u2011resistant strains. Keywords: Acinetobacter, critical care, drug resistance, mechanical ventilation, respiratory infections.<\/p>\r\n\r\n\r\n\r\n
Sannathimmappa MB1*, Vinod Nambiar , Aravindakshan R, Al-Kasaby M.<\/p>\r\n\r\n\r\n\r\n